Product Catalog / SARM and SERM

Andarine S-4

Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound. Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects. This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.

Molecular Formula: C19H18F3N3O6
Molecular Weight: 441.363 g/mol
PubChem SID: 9824562
Synonyms: (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; 401900-40-1; GTX-007; S-4

LGD-4033

LGD-4033 (known too as VK5211) is an investigational selective androgen receptor modulator (SARM). LGD-4033 binds to the androgen receptor, exhibiting similar effects as testosterone. The advantage a SARM like LGD has over testosterone is the difference in activity. LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds to the androgen receptor with high affinity and selectivity. It demonstrates anabolic activity in muscles, anti-resorptive and anabolic activity in bones and a robust selectivity for muscle and bone versus prostate and sebaceous glands.

IUPAC Name: 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Molecular Formula: C14H12F6N2O
Molecular Weight: 338.253 g/mol
PubChem SID: 44137686
Synonyms: Ligandrol; 1165910-22-4; ZINC95830588

Ostarine MK-2866

Ostarine, also known as MK-2866 is a SARM (selective androgen receptor module) created by GTx to avoid and treat muscle wasting. It can later on be a cure for avoiding atrophy (total wasting away of a body part), cachexia, sarcopenia and Hormone or Testosterone Replacement Therapy. SARMS bind to the androgen receptor (AR) and shows osteo (bone) and myo (muscular) selective anabolic activity. The tying and stimulation intensifies protein synthesis and builds muscle.

AA Sequence: JNGVJMBLXIUVRD-UHFFFAOYSA-N
IUPAC Name: 3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
Molecular Formula: C19H14F3N3O3
Molecular Weight: 389.334 g/mol
PubChem SID: 11552833
Synonyms: n-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide; Enobosarm; MK-2866; S-22; GTx-024

RAD140 Testolone

RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer. RAD140 is one of the newest SARMS, and its objective is to give a blast of testosterone without the negative side effects associated to steroid use. Hence the reason why it is an alternative to testosterone replacement therapy. Specifically, it has been shown to interact with hormonal receptors in the tissues in the same way as a large doses of testosterone do. Furthermore, it also exhibited a greater anabolic effect than testosterone, and a more reinforced effect as well.

IUPAC Name: 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile
Molecular Formula: C20H16ClN5O2
Molecular Weight: 393.831 g/mol
PubChem SID: 44200882
Synonyms: UNII-4O87Q44KNC; 4O87Q44KNC; CHEMBL1672635

YK11

YK-11 is a synthetic, steroidal selective androgen receptor modulator (SARM). It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR. The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone (DHT) in this regard.

IUPAC Name: methyl (2E)-2-[(8R,9S,10R,13S,14S,17S)-2'-methoxy-2',13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5'-1,3-dioxolane]-4'-ylidene]acetate
Molecular Formula: C25H34O6
Molecular Weight: 430.541 g/mol
PubChem SID: 313371232
Synonyms: (17alpha,20E)-17,20-((1-Methoxyethylidene)bis(oxy))-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester; 19-Norpregna-4,20-diene-21-carboxylic acid, 17,20-((1-methoxyethylidene)bis(oxy))-3-oxo-, methyl ester, (17alpha,20E)-; Z9748J6B0R

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