Product Catalog / rHGH, IGF and MGF

DES (1-3) IGF-1

DES(1-3)IGF-1 is a naturally occurring, endogenous protein, as well as drug, and truncated analogue of insulin-like growth factor 1 (IGF-1). DES(1-3)IGF-1 lacks the first three amino acids at the N-terminus of IGF-1 (for a total of 67 amino acids, relative to the 70 of IGF-1). As a result of this difference, it has considerably reduced binding to the insulin-like growth factor-binding proteins (IGFBPs) and enhanced potency (about 10-fold in vivo) relative to IGF-1!

AA Sequence: TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA
Molecular Formula: C319H501N91O96S7
Molecular Weight: 7371.4 g/mol
Synonyms: IGF-1 DES(1-3); DES1-3; DES 1-3; DES (1-3); IGF-1 (4-70)

IGF-1 LR3

IGF-1 LR3 (also named Long arginine 3-IGF-1 or as LR3-IGF-1), is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) ("long"), for a total of 83 amino acids (relative to the 70 of IGF-1). The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability. As a result, it is approximately three times more potent than IGF-1, and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1's half-life of about 12–15 hours).

AA Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
Molecular Formula: C400H625N111O115S9
Molecular Weight: 9117.5 g/mol
Synonyms: Long arginine 3-IGF-1; LR3-IGF-1; Long R3 IGF-1; Insulin-Like Growth Factor-I Long Arg3; Long Arg3 IGF-1

MGF (IGF-1 EC)

Mechano growth factor (MGF) is a novel splice variant of the Insulin-Like Growth Factor-1 (IGF-1), also known as IGF-1 Ec in humans and IGF-1Eb in rodents. It is actually originally called MGF because the RNA form of it is expressed in muscle tissues in response to the overload or damage of muscle growth tissue. In the postischemic hippocampus the levels of MGF transcript and the peptide were increased selectively in neurons resistant to the ischemic insult. While MGF is known for its regenerative potential in skeletal muscle, we show here for the first time a role for this IGF-1 isoform in the brain. We demonstrate that the 24 amino acid C-terminal domain unique to this isoform can function as an autonomous biologically active peptide and is an extremely potent neuroprotective agent in vivo and in vitro. The C-terminal peptide of the MGF is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame in which a specific C-terminal sequence (E-domain) is encoded by exon 5 and the first part of the exon 6. A single dose of chemically stabilized C-terminal MGF peptide prevented neurodegeneration of vulnerable CA1 neurones following global brain ischemia in vivo. The unilateral injection often produced the bilateral neuroprotection. Therefore, this C-terminal MGF peptide may not need to be targeted directly into its site of action. This C-terminal MGF peptide was also highly protective in a hippocampal slice model of oxidative stress and NMDA-induced neurodegeneration in vitro. Protection provided by the C-terminal MGF was not inhibited by the blockade of the canonical ligand binding site on the IGF-1 receptor. Another interesting point in MGF is that, because of the E domain it contains, MGF can act on muscles independently from the rest of the molecule. Furthermore, MGF can elicit very different effects with mGF promoting satellite cells proliferation and IGF-1 inducing differentiation.

AA Sequence: H-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
Molecular Formula: C121H200N42O39
Molecular Weight: 2867.14±3.7 g/mol
Synonyms: Mechano Growth Factor; MGF

PEG-MGF (IGF-1 EC)

PEG MGF is a splice variant of the IGF produced by a frame shift if the IGF gene and PEGylated to improve stability. PEG-MGF, or PEGylated Mechano Growth Factor, is a new and innovative form of the IGF produced by a frame shift if the IGF gene, namely Mechano Growth Factor (MGF), which is PEGylated to improve stability that outperforms natural MGF many times over. MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes. Research has shown that PEG-MGF helps increase the muscle stem cell count, so that more may fuse and become part of adult muscle cells.

AA Sequence: PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-D-Arg-D-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
Molecular Formula: C121H200N42039
Molecular Weight: 2948.15 g/mol
Synonyms: Pegylated MGF; PEG IGF-1 Ec; Pegylated Mechano Growth Factor

rHGH (Somatotropin, Human Growth Hormone)

HGH, Growth hormone (GH), or also known as Somatotropin, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. It is a type of mitogen which is specific only to certain kinds of cells. Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. GH is a stress hormone that raises the concentration of glucose and free fatty acids. It also stimulates production of IGF-1.

AA Sequence: FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPT PSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEG IQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIV QCRSVEGSCGF
Molecular Formula: C990H1532N262O300S7
Molecular Weight: 22129.0 Da
Synonyms: Somatotropin; Human Growth Hormone; Growth Hormone; HGH; GH

All rights reserved  ©  2015-2016 Eurolabs Peptides