Study dossier

Biological Activities of the Tripeptide GHK and the Cosmetic Applications of the GHK Peptide

Pickart L, Margolina A · Cosmetics (2018)

doi:10.3390/cosmetics5010011

The human tri-peptide GHK and tissue remodeling

Pickart L · J Biomater Sci Polym Ed (2008)

doi:10.1163/156856208784909435

Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

Jastreboff AM, Kaplan LM, Frías JP et al. · N Engl J Med (2023)

doi:10.1056/NEJMoa2301972

Retatrutide, a GIP/GLP-1/glucagon receptor agonist, for people with type 2 diabetes: a phase 2 randomised trial

Rosenstock J, Frias J, Jastreboff AM et al. · Lancet (2023)

doi:10.1016/S0140-6736(23)01053-X

Peptide regulation of aging: 35-year research experience

Khavinson VKh · Bull Exp Biol Med (2014)

doi:10.1007/s10517-013-2326-7

Effect of Epithalon on biomarkers of aging, life span and spontaneous tumor incidence in female CBA mice

Anisimov VN, Khavinson VKh, Popovich IG et al. · Mech Ageing Dev (2003)

doi:10.1016/S0047-6374(02)00134-1

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Lee C, Zeng J, Drew BG et al. · Cell Metab (2015)

doi:10.1016/j.cmet.2015.02.009

Sermorelin: A better approach to management of adult-onset growth hormone insufficiency?

Walker RF · Clin Interv Aging (2006)

doi:10.2147/ciia.2006.1.4.307

Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract

Sikiric P, Seiwerth S, Rucman R et al. · Curr Pharm Des (2011)

doi:10.2174/138161211796196954

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration

Chang CH, Tsai WC, Lin MS et al. · J Appl Physiol (2011)

doi:10.1152/japplphysiol.00945.2010

Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues

Goldstein AL, Hannappel E, Kleinman HK · Trends Mol Med (2005)

doi:10.1016/j.molmed.2005.07.004

Thymosin beta-4: structure, function, and biological properties supporting current and future clinical applications

Crockford D, Turjman N, Allan C, Angel J · Ann N Y Acad Sci (2010)

doi:10.1111/j.1749-6632.2010.05492.x

PNC-27 anticancer peptide selectively targets HDM-2 in cancer cell membranes

Sookoian S, Pirola CJ et al. · Curr Pharm Biotechnol (2010)

doi:10.2174/138920110793262060

Thymosin alpha 1 in the treatment of cancer: from basic research to clinical application

Garaci E, Pica F, Sinibaldi-Vallebona P et al. · Crit Rev Immunol (2010)

doi:10.1615/CritRevImmunol.v30.i2.70

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy

Karaa A, Haas R, Goldstein A et al. · Neurology (2018)

doi:10.1212/WNL.0000000000005255

Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide

Daubert MA, Yow E, Dunn G et al. · Circ Heart Fail (2017)

doi:10.1161/CIRCHEARTFAILURE.117.004389

Reduced intravenous glutathione in the treatment of early Parkinson's disease

Sechi G, Deledda MG, Bua G et al. · Prog Neuropsychopharmacol Biol Psychiatry (1996)

doi:10.1016/S0278-5846(96)00103-0

Acetyl Hexapeptide-3 and Acetyl Octapeptide-3 in cosmetic anti-wrinkle formulations — comparative study

Wang Y, Wang M, Xiao S et al. · Int J Cosm Sci (2013)

doi:10.1111/ics.12042

PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation

Dalmasso G, Charrier-Hisamuddin L, Nguyen HTT et al. · Gastroenterology (2008)

doi:10.1053/j.gastro.2007.10.026

Semax, an ACTH(4-10) analogue with nootropic properties

Eremin KO, Kudrin VS, Saransaari P et al. · Bull Exp Biol Med (2005)

doi:10.1007/s10517-005-0241-2

Efficacy and possible mechanisms of action of Selank in generalized anxiety disorder

Zozulya AA, Neznamov GG, Syunyakov TS et al. · Bull Exp Biol Med (2008)

doi:10.1007/s10517-008-0227-y

Effects of delta sleep-inducing peptide on insomnia: a clinical study

Schneider-Helmert D, Schoenenberger GA · Eur Neurol (1986)

doi:10.1159/000116090

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

Vandamme D, Landuyt B, Luyten W, Schoofs L · Cell Immunol (2012)

doi:10.1016/j.cellimm.2012.11.009

Pinealon protects neurons against hypoxia and reactive oxygen species in vitro

Khavinson VKh, Yashin AI, Mikhailova ON et al. · Neuroendocrinol Lett (2011)

Peptide regulation of aging: 35-year research experience

Khavinson VKh · Bull Exp Biol Med (2014)

doi:10.1007/s10517-013-2326-7

Targeted induction of apoptosis in adipose tissue vasculature by a designer peptide (Adipotide) — preclinical proof of concept

Barnhart KF, Christianson DR, Hanley PW et al. · Sci Transl Med (2011)

doi:10.1126/scitranslmed.3002621

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Baar MP, Brandt RMC, Putavet DA et al. · Cell (2017)

doi:10.1016/j.cell.2017.02.031

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GHRH, in healthy adults

Teichman SL, Neale A, Lawrence B et al. · J Clin Endocrinol Metab (2006)

doi:10.1210/jc.2005-1536

Ipamorelin, the first selective growth hormone secretagogue

Raun K, Hansen BS, Johansen NL et al. · Eur J Endocrinol (1998)

doi:10.1530/eje.0.1390552

Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)

Wilding JPH, Batterham RL, Calanna S et al. · N Engl J Med (2021)

doi:10.1056/NEJMoa2032183

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6)

Marso SP, Bain SC, Consoli A et al. · N Engl J Med (2016)

doi:10.1056/NEJMoa1607141

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT)

Lincoff AM, Brown-Frandsen K, Colhoun HM et al. · N Engl J Med (2023)

doi:10.1056/NEJMoa2307563

Effects of Tesamorelin on Visceral Fat in HIV-Infected Adults with Excess Abdominal Fat

Falutz J, Allas S, Blot K et al. · N Engl J Med (2007)

doi:10.1056/NEJMoa072375

Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Adults with NAFLD

Stanley TL, Feldpausch MN, Oh J et al. · JAMA (2014)

doi:10.1001/jama.2014.8334