EL-15· Research peptide
Illustrative image; appearance and packaging may vary. 10 unlabelled vials, labelled only on the kit packaging. The selected strength applies.
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Research Use Only (RUO)
EL-15 · Reference data
SNARE-Komplex-Modulator (Octapeptid)
Aliases: Acetyl Octapeptide-3
SNAP-8, also known as Acetyl Octapeptide-3, is a peptide made of eight amino acids. Its name refers to SNAP-25, a neuronal protein of the SNARE machinery. This connection makes the short molecule interesting for cosmetic research: a defined, small structure meets a cellular process that controls vesicle fusion.
The NIH/NCATS GSRS entry lists SNAP-8 as a brand synonym of Acetyl Octapeptide-3 and classifies the reference substance as a peptide (GSRS entry for Acetyl Octapeptide-3). The name describes an acetylated peptide made of eight amino acid residues. The acetyl group is part of the substance's identity.
SNAP-8 is clearly distinct from SNAP-25. SNAP-25 is a neuronal protein associated with the SNARE machinery. The 25 is part of the protein's name and does not indicate the length of SNAP-8. SNAP-8 remains a separate octapeptide with eight amino acid residues.
The short chain is typical of cosmetic peptides. It can be incorporated into different formulations and remains structurally straightforward. Precisely this combination of a defined structure and a biological reference makes SNAP-8 attractive for formulation research.
SNARE proteins mediate the fusion of vesicles with the cell membrane. At nerve endings, this process is a prerequisite for the release of neurotransmitters. SNAP-25 is part of this machinery and is the reference behind SNAP-8's name.
The cosmetic interest in this biology is closely tied to expression lines. Repeated facial muscle movements shape lines, and the idea of modulating signal transmission at the neuromuscular junction is a natural research focus. SNAP-8 is not botulinum toxin, but an octapeptide.
The human studies examine complete formulations and their effect on the skin's appearance. The focus is therefore on the formulation as a whole and on the delivery system.
Both investigations tested hyaluronic acid microneedles in which Acetyl Octapeptide-3 was combined with other ingredients. The differences in design are important for interpretation:
| Study | Design | Formulation tested | Result |
|---|---|---|---|
| 2019 | 12 weeks | Acetyl Octapeptide-3 with other peptides, adenosine and algae extracts | Improvement in wrinkles and instrumentally measured skin parameters |
| 2024 | 24 healthy participants, 28 days, eye area | Acetyl Octapeptide-3, vitamin C derivative and cyclic lysophosphatidic acid versus hyaluronic acid-only microneedles | Active combination performed better on measured wrinkle parameters |
The twelve-week investigation assessed the complete patch (2019 clinical study), while the 2024 comparative study tested the active combination against hyaluronic acid-only microneedles (2024 comparative study). In both cases, the formulation as a whole is the focus.
The stratum corneum is an effective barrier. Microneedles penetrate it and enable distribution of the formulation in superficial skin layers. In both studies, the patch was therefore not just a carrier but part of the tested system. The results apply to the tested patch and not automatically to any other delivery format.
Both studies are relevant to cosmetic research because they test real formulations under study conditions. They show that Acetyl Octapeptide-3 can be integrated into microneedle delivery systems and, in combination with hyaluronic acid and other ingredients, can be part of a tested cosmetic concept.
The studies do not test SNAP-8 in isolation. The reported improvements relate to the complete formulation and the delivery system; an independent effect of the peptide is therefore not established. For cosmetics, this formulation context is interesting because it shows how the peptide is used in a real product concept.
The shop offers SNAP-8 in this variant for research. The figure refers to the peptide amount per vial, not a concentration. Buy SNAP-8 now and view the variant in the shop.
No analytical batch data is currently published for this product.
No. SNAP-8 is Acetyl Octapeptide-3, an octapeptide made of eight amino acids. SNAP-25 is a neuronal protein of the SNARE machinery; the 25 is part of the protein name and not an indication of SNAP-8's length.
It describes an acetylated peptide made of eight amino acid residues. According to GSRS, SNAP-8 is a brand synonym of Acetyl Octapeptide-3; the acetyl group is part of the molecular identity.
Hyaluronic acid microneedle patches containing Acetyl Octapeptide-3 and other ingredients were tested. The 2019 and 2024 studies report improvements in wrinkles and skin parameters for the complete formulations.
SNAP-8 is not botulinum toxin. The microneedle studies do not establish a botulinum toxin-like clinical effect or equivalence for the isolated peptide.
Microneedles penetrate the stratum corneum and bring the formulation into superficial skin layers. In the studies, the delivery system was part of the tested unit.
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